PhD Position Monitoring and Control of Bench-scale CHO Cell Culture

Job description

In this PhD project you will working on developing and employing real-time monitoring and automated control of process flows in bench-scale CHO cell cultures for monoclonal antibody (mAb) production. You will be responsible for developing models to monitor key analytes in a biopharmaceutical process, including nutrients and product quality attributes. This means you will dive into process development for a standardized cell line and work on robust and transferable PAT monitoring models. Moreover, you will aim to use the real-time data to design strategies that allow you to (automatically) steer the process towards optimized productivity while maintaining product quality. This project includes wet lab (process development, data acquisition) and dry lab activities (spectroscopy-based model building, control).

Research group

The Klijn lab works on the implementation of real-time analytics in bioprocesses to faciliate automated monitoring and control strategies. We work on a broad range of processes, from microbial to mammalian, and we use a variety of process analytical techniques.    

Job requirements 

We are looking for an outstanding and creative researcher with a strong affinity to work at the boundary of multiple disciplines, namely bioprocessing engineering, multivariate data analysis, and automated control. This includes the internal motivation to expand your horizon, ablilty to learn quickly, and strong communication skills to easily connect with other experts in and outside the research group.

Click here for the full job description and application procedure.
Submission is possible until 8 April 2026