PhD Position High-speed Single-molecule Super-resolution Microscopy with Neuromorphic Vision Sensors

Interested in ultrafast single-molecule super-resolution bioimaging, novel sensors and image analysis? Curious about interdisciplinary biophysics research? We are looking for you!

Job description

Super-resolution and single-molecule microscopy play a crucial role in understanding nanoscale organization in cells. However, there is a detrimental trade-off between resolution and imaging speed, and super-resolution microscopy excels only in fixed, lifeless cells.

Neuromorphic vision sensors “see” at the molecular level when something is moving or changing - like the human eye. By recording logarithmic intensity changes per pixel (events) asynchronously instead of conventional camera frames, they are extremely fast, data efficient and have a wide dynamic range.

The candidate will investigate these high-speed event-based cameras and integrate them for next-level stochastic single-molecule microscopy in (living) cells. The work includes responsibility for a microscope setup and integration of the cameras into data acquisition workflows as well as development of corresponding new data analysis strategies. Experiments with controlled in vitro samples and live cells are facilitated by an established toolbox of advanced labeling in the lab and available cell culture/cell biology technician support.  

The position is in the group of Dr. Kristin Grussmayer in the Department of Bionanoscience and the Kavli Institute of Nanoscience Delft as part of a team working on "Neuromorphic vision sensors for single-molecule bioimaging". We are an experimental biophysics lab employing super-resolution imaging techniques and fast 3D microscopy to improve understanding of cellular structures at the nanometer scale. As a young research group, we offer an interactive, supportive and collegial environment. We perform multidisciplinary research where we combine techniques from molecular/cell biology, (physical/bio) chemistry, (bio)physics, optics and machine learning. To ensure interactions and exchange of ideas, we have regular group and department meetings as well as meetings with the experimental and computational groups we collaborate with.

Click here for the full job description and application procedure.
Submission is possible until 22 April 2026